RT Journal Article
SR Electronic
T1 Diet pattern and prodromal features of Parkinson disease
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP e2095
OP e2108
DO 10.1212/WNL.0000000000010523
VO 95
IS 15
A1 Molsberry, Samantha
A1 Bjornevik, Kjetil
A1 Hughes, Katherine C.
A1 Healy, Brian
A1 Schwarzschild, Michael
A1 Ascherio, Alberto
YR 2020
UL http://n.neurology.org/content/95/15/e2095.abstract
AB Objective To assess the relationship between diet pattern and prodromal Parkinson disease (PD) features.Methods These analyses include 47,679 participants from the Nurses' Health Study and the Health Professionals Follow-up Study. Since 1986, both cohorts have collected dietary information every 4 years and calculated scores for adherence to different diet patterns, including the alternate Mediterranean diet (aMED) and the Alternative Healthy Eating Index (AHEI). In 2012, participants responded to questions regarding constipation and probable REM sleep behavior disorder. For a subset of 17,400 respondents to the 2012 questionnaire, 5 additional prodromal features of PD were assessed in 2014 to 2015. We used multinomial logistic regression to estimate the association between baseline (1986) diet pattern score quintiles and number of prodromal features (0, 1, 2, or ≥3) in 2012 to 2015. Additional analyses investigated the association between long-term adherence to these dietary patterns over 20 years and prodromal features suggestive of PD.Results In a comparison of extreme aMED diet quintiles, the odds ratio for ≥3 vs 0 features was 0.82 (95% confidence interval [CI] 0.68–1.00, false discovery rate [FDR]–adjusted ptrend = 0.03) at baseline and 0.67 (95% CI 0.54–0.83, FDR-ptrend < 0.001) for long-term diet; results were equally strong for the association with AHEI scores. Higher adherence to these diets was inversely associated with individual features, including constipation, excessive daytime sleepiness, and depression.Conclusions The inverse association between these diet patterns and prodromal PD features is consistent with previous findings and suggests that adherence to a healthy diet may reduce the occurrence of nonmotor symptoms that often precede PD diagnosis.AHEI=Alternative Healthy Eating Index; aMED=alternate Mediterranean diet; BMI=body mass index; CI=confidence interval; DLB=dementia with Lewy bodies; FDR=false discovery rate; FFQ=food frequency questionnaire; HPFS=Health Professionals Follow-up Study; NHS=Nurses' Health Study; OR=odds ratio; PD=Parkinson disease; pRBD=probable RBD; RBD=REM sleep behavior disorder