PT  - JOURNAL ARTICLE
AU  - Na, Muzi
AU  - Wu, Jing
AU  - Li, Mengying
AU  - Hinkle, Stefanie N.
AU  - Zhang, Cuilin
AU  - Gao, Xiang
TI  - New onset of restless legs syndrome in pregnancy in a prospective multiracial cohort: Incidence and risk factors
AID  - 10.1212/WNL.0000000000011082
DP  - 2020 Nov 11
TA  - Neurology
PG  - 10.1212/WNL.0000000000011082
4099  - http://n.neurology.org/content/early/2020/11/11/WNL.0000000000011082.short
4100  - http://n.neurology.org/content/early/2020/11/11/WNL.0000000000011082.full
AB  - Objective: To determine whether the incidence and risk factors of RLS in pregnancy differ by race/ethnicity, we estimated relative risks of demographic, socioeconomic, and nutritional factors in association with risk of any incident RLS in pregnancy in a cohort of 2,704 health pregnant women without prior RLS.Design: Using data from the multicenter, multiracial NICHD Fetal Growth Studies - Singletons, we examined the incidence of RLS from early pregnancy to near delivery through up to 6 assessments. Multivariable Poisson models with robust variance were applied to estimate relative risks (RR).Results: The cumulative incidence of RLS in pregnancy was 18.1% for all women, 20.3% for whites, 15.4% for blacks, 17.1% for Hispanics, and 21.1% for Asians. Among Hispanic women, older age (RR (reference≤25y): 25-35y, 1.51; 95%CI, 1.05, 2.16; ≥35y, 1.58; 95%CI, 0.93, 2.68), iron deficiency anemia (RR (reference=no): yes, 2.47; 95%CI, 1.31, 4.64), and greater total skinfolds of the sub-scapular and triceps sites, independent of BMI, (RR (reference quartile 1): quartile 5, 2.54; 95%CI, 1.30, 4.97; p-trend = 0.01) were associated with higher risk of RLS, while multiparity was associated with a lower risk (RR (reference=nulliparity): 0.69; 95%CI, 0.50, 0.96). In Black women, greater skinfolds and waist circumference were associated with higher risk of pregnancy RLS, though the trends were less clear.Conclusions: The incidence of RLS in pregnancy was high and differed by race/ethnicity, which is likely accounted for by differences in other risk factors, such as age, parity, and nutritional factors.