RT Journal Article
SR Electronic
T1 Cerebellar atrophy following acute 0intoxication with phenytoin
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 432
OP 432
DO 10.1212/WNL.39.3.432
VO 39
IS 3
A1 Masur, H.
A1 Elger, C. E.
A1 Ludolph, A. C.
A1 Galanski, M.
YR 1989
UL http://n.neurology.org/content/39/3/432.abstract
AB A patient developed marked cerebellar atrophy after a single suicidal intoxication with 7 grams phenytoin. The clinical signs of cerebellar dysfunction subsided very slowly and incompletely within 18 months. We documented the cerebellar atrophy by CTs 4 weeks and 1 year after the intoxication, and we suggest that a single severe acute intoxication with phenytoin may directly cause cerebellar degeneration.