RT Journal Article
SR Electronic
T1 Association of Migraine With Incident Hypertension After Menopause
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP e34
OP e41
DO 10.1212/WNL.0000000000011986
VO 97
IS 1
A1 MacDonald, Conor James
A1 El Fatouhi, Douae
A1 Madika, Anne-Laure
A1 Fagherazzi, Guy
A1 Kurth, Tobias
A1 Severi, Gianluca
A1 Boutron-Ruault, Marie-Christine
YR 2021
UL http://n.neurology.org/content/97/1/e34.abstract
AB Objective Migraine has been identified as a potential risk factor for hypertension in prospective studies. In women, migraine prevalence decreases after menopause, but no studies have determined whether migraine is associated with hypertension after menopause. This study sought to determine whether history of migraine was associated with an increased risk of hypertension among menopausal women.Methods We assessed associations between migraine and hypertension in a longitudinal cohort study of 56,202 menopausal women participating in the French E3N cohort, with follow-up beginning in 1993. We included women who did not have hypertension or cardiovascular disease at the time of menopause. Migraine was classified as ever or never at each questionnaire cycle. Cox proportional hazards models were used to investigate relations between migraine and hypertension, controlling for potential confounding. A secondary analysis with baseline in 2011 considered aura status, grouping participants reporting migraine as migraine with aura, migraine without aura, or unknown migraine type.Results During 826,419 person-years, 12,501 cases of incident hypertension were identified, including 3,100 among women with migraine and 9,401 among women without migraine. Migraine was associated with an increased risk of hypertension in menopausal women (hazard ratio [HR]migraine 1.29 [95% confidence interval 1.24, 1.35]) and was consistent in post hoc sensitivity analyses, such as when controlling for common migraine medications. Associations between migraine and hypertension were similar whether or not women reported aura (HRmigraine aura 1.54 [1.04, 2.30], HRmigraine no aura 1.32 [0.87, 2.02], p heterogeneity 0.60). Associations were slightly stronger among ever users of menopausal hormone therapy (HRmigraine 1.34 [1.27, 1.41]) than among never users (HRmigraine 1.19 [1.11, 1.28]).Conclusions Migraine was associated with an increased risk of hypertension among menopausal women. In secondary analysis, we did not observe a significant difference between migraine with aura and migraine without aura.BMI=body mass index; CVD=cardiovascular disease; E3N=Etude Épidémiologique de Femmes de la Mutuelle Générale de l'Education; HR=hazard ratio; MGEN=Mutuelle Générale de l'Education Nationale; MHT=menopausal hormone therapy; PY=person-years; WHI=Women's Health Initiative