RT Journal Article
SR Electronic
T1 An estimate of the incidence of dementia in idiopathic Parkinson's disease
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 1513
OP 1513
DO 10.1212/WNL.40.10.1513
VO 40
IS 10
A1 Mayeux, R.
A1 Chen, J.
A1 Mirabello, E.
A1 Marder, K.
A1 Bell, K.
A1 Dooneief, G.
A1 Cote, L.
A1 Stern, Y.
YR 1990
UL http://n.neurology.org/content/40/10/1513.abstract
AB The proportion of patients with idiopathic Parkinson's disease (PD) who are considered demented ranges from 10% to 15%. Because dementia may affect survival in PD, the incidence rate of dementia, rather than proportion, would be a more accurate measure of disease frequency. We previously estimated the proportion of patients with PD and dementia to be 10.9% from the records of a cohort with the idiopathic form of PD in a major medical center. We reviewed the clinical records of this cohort after 4 years and 9 months to estimate the incidence rate of dementia. We identified 65 new cases of dementia from the 249 patient-records available. Using the number of person-years of follow-up for each case as the denominator, we estimated the overall incidence rate to be 69 per 1,000 person-years of observation. The mean age of this cohort was 71.4 years. The cumulative incidence of dementia increased with age. By 85 years of age, over 65% of the surviving members of the cohort were demented. The age-specific incidence rates for dementia in this cohort of PD were significantly greater than for a similarly aged cohort of healthy elderly people. The age-specific standard morbidity ratios indicated that, compared with people of similar ages, patients with PD have the highest increase in risk for dementia between ages 65 and 75.