RT Journal Article
SR Electronic
T1 Variable expression of Parkinson's disease
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 1529
OP 1529
DO 10.1212/WNL.40.10.1529
VO 40
IS 10
A1 Jankovic, J.
A1 McDermott, M.
A1 Carter, J.
A1 Gauthier, S.
A1 Goetz, C.
A1 Golbe, L.
A1 Huber, S.
A1 Koller, W.
A1 Olanow, C.
A1 Shoulson, I.
A1 Stern, M.
A1 Tanner, C.
A1 Weiner, W.
A1 Parkinson Study Group
YR 1990
UL http://n.neurology.org/content/40/10/1529.abstract
AB The DATATOP database, which includes clinical information on 800 patients with early untreated Parkinson's disease (PD), is well suited to explore clinical heterogeneity in PD. Patients with early-onset PD (≤40 years, N = 33) reached the same level of disability as the late-onset PD (≥70 years, N = 85) group at a significantly slower rate (2.9 vs. 1.7 years). Early-onset PD patients functioned cognitively better than late-onset PD patients. Bradykinesia, and postural instability and gait difficulty (PIGD), were more common at onset in patients with a rapid rate of disease progression (“malignant PD”; duration of symptoms <1 year and Hoehnflahr stage of 2.5, N = 11) as compared with those with a relatively slow rate of progression (“benign PD”; duration of symptoms >4 years, N = 65). Comparisons of tremor-dominant PD (mean tremor score/ mean PIGD score ≤1.5, N = 441) with the PIGD-dominant type (mean tremor score/mean PIGD score ≥1.0, N = 233) provided support for the existence of clinical subtypes. The PIGD group reported significantly greater subjective intellectual, motor, and occupational impairment than the tremor group. Stage II patients had higher depression scores than stage I patients. Among the patients participating in the DATATOP, older age at onset with bradykinesia, or with the PIGD form of PD, is associated with more functional disability than when the symptoms are dominated by tremor or begin at a younger age.