RT Journal Article SR Electronic T1 Response of the Lambert‐Eaton myasthenic syndrome to treatment of associated small‐cell lung carcinoma JF Neurology JO Neurology FD Lippincott Williams & Wilkins SP 1552 OP 1552 DO 10.1212/WNL.40.10.1552 VO 40 IS 10 A1 Chalk, C. H. A1 Murray, N.M.F. A1 Newsom-Davis, J. A1 O'Neill, J. H. A1 Spiro, S. G. YR 1990 UL http://n.neurology.org/content/40/10/1552.abstract AB We evaluated the outcome in 16 patients with Lambed-Eaton myasthenic syndrome (LEMS) associated with histologically verified small-cell carcinoma (SCC). Thirteen patients received specific tumor therapy (chemotherapy, radiation therapy, or resection) and most also received pharmacologic and immunologic treatment for LEMS. Seven of 11 patients surviving for more than 2 months after tumor therapy showed substantial neurologic improvement (1 patient being in complete remission at 7 years); in 3 of 11 improvement was transient. An EMG index of disease severity (compound muscle action potential amplitude in abductor digiti minimi) was significantly increased at final follow-up (p < 0.01; n = 11). A pretreatment amplitude >3.0 m V was a good prognostic sign. We conclude that a combined treatment approach in SCC-LEMS usually results in neurologic improvement.