RT Journal Article
SR Electronic
T1 Seizure recurrence after a 1st unprovoked seizure
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 1163
OP 1163
DO 10.1212/WNL.40.8.1163
VO 40
IS 8
A1 W. Allen Hauser
A1 Stephen S. Rich
A1 John F. Annegers
A1 V. Elving Anderson
YR 1990
UL http://n.neurology.org/content/40/8/1163.abstract
AB We followed 208 patients identified on the day of their 1st unprovoked seizure for a mean duration of 4 years. Seizures recurred in 64. Recurrence risks were estimated to be 14%, 29%, and 34% at 1, 3, and 5 years following the 1st episode. A history of previous neurologic insult (remote symptomatic) was associated with a 2.5-fold increased risk of recurrence. Among idiopathic cases, a sibling with epilepsy, a generalized spike and wave EEG, or a history of acute symptomatic seizure increased risk for recurrence. Among remote symptomatic cases, status epilepticus, a prior acute symptomatic seizure, or Todd's paresis increased risk. Depending upon clinical features, recurrence risk at 5 years following a 1st seizure ranged from 23% to 80%. Treatment with anticonvulsant medication was not associated with a decrease in recurrence risks.