PT  - JOURNAL ARTICLE
AU  - Wallach, Asya
AU  - Stember, Danielle
AU  - Valentine, David
AU  - Howard, Jonathan
TI  - Differential Diagnosis of MRI Corticospinal Tract Abnormalities (P2.201)
DP  - 2017 Apr 18
TA  - Neurology
PG  - P2.201
VI  - 88
IP  - 16 Supplement
4099  - http://n.neurology.org/content/88/16_Supplement/P2.201.short
4100  - http://n.neurology.org/content/88/16_Supplement/P2.201.full
SO  - Neurology2017 Apr 18; 88
AB  - Objective: To present clinical and radiographic descriptions of conditions that may feature corticospinal tract abnormalities observed on magnetic resonance imaging (MRI).Background: Corticospinal tract lesions have a broad differential diagnosis, including neurodegenerative diseases, toxic/metabolic derangements, malignancies, autoimmune diseases, infectious diseases, and neurogenetic conditions.Design/Methods: Review of clinical presentations and brain MRIs.Results: Conditions that have been associated with corticospinal tract hyperintensities on brain MRI include: amyotrophic lateral sclerosis, primary lateral sclerosis, heroin leukoencephalopathy, brainstem glioma, neuro-Behcets, HIV infection, neuromyelitis optica, Krabbe A disease, adult polyglucosan body disorder, X-linked Charcot-Marie-Tooth disease, Behr syndrome, Whipple disease, and sequela of liver transplantation. We present representative images and discuss clinical and radiographic features that distinguishing these conditions.Conclusions: Corticospinal tract lesions have a heterogenous etiology, with widely different treatments and prognoses. An understanding of these potential etiologies will assist neurologists confronted with this imaging finding.Study Supported by: None.Disclosure: Dr. Wallach has nothing to disclose. Dr. Stember has nothing to disclose. Dr. Valentine has nothing to disclose. Dr. Howard has nothing to disclose.