RT Journal Article
SR Electronic
T1 Differential Diagnosis of MRI Corticospinal Tract Abnormalities (P2.201)
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP P2.201
VO 88
IS 16 Supplement
A1 Wallach, Asya
A1 Stember, Danielle
A1 Valentine, David
A1 Howard, Jonathan
YR 2017
UL http://n.neurology.org/content/88/16_Supplement/P2.201.abstract
AB Objective: To present clinical and radiographic descriptions of conditions that may feature corticospinal tract abnormalities observed on magnetic resonance imaging (MRI).Background: Corticospinal tract lesions have a broad differential diagnosis, including neurodegenerative diseases, toxic/metabolic derangements, malignancies, autoimmune diseases, infectious diseases, and neurogenetic conditions.Design/Methods: Review of clinical presentations and brain MRIs.Results: Conditions that have been associated with corticospinal tract hyperintensities on brain MRI include: amyotrophic lateral sclerosis, primary lateral sclerosis, heroin leukoencephalopathy, brainstem glioma, neuro-Behcets, HIV infection, neuromyelitis optica, Krabbe A disease, adult polyglucosan body disorder, X-linked Charcot-Marie-Tooth disease, Behr syndrome, Whipple disease, and sequela of liver transplantation. We present representative images and discuss clinical and radiographic features that distinguishing these conditions.Conclusions: Corticospinal tract lesions have a heterogenous etiology, with widely different treatments and prognoses. An understanding of these potential etiologies will assist neurologists confronted with this imaging finding.Study Supported by: None.Disclosure: Dr. Wallach has nothing to disclose. Dr. Stember has nothing to disclose. Dr. Valentine has nothing to disclose. Dr. Howard has nothing to disclose.