PT  - JOURNAL ARTICLE
AU  - Sasaki, Ryogen
AU  - Morimoto, Satoru
AU  - Ozawa, Fumiko
AU  - Okano, Hideyuki
AU  - Yoshida, Mari
AU  - Ishiura, Hiroyuki
AU  - Tsuji, Shoji
AU  - Kuzuhara, Shigeki
AU  - Kokubo, Yasumasa
TI  - <em>APOE</em> Alleles With Tau and Aβ Pathology in Patients With Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex in the Kii Peninsula
AID  - 10.1212/WNL.0000000000201156
DP  - 2022 Nov 29
TA  - Neurology
PG  - e2437--e2442
VI  - 99
IP  - 22
4099  - http://n.neurology.org/content/99/22/e2437.short
4100  - http://n.neurology.org/content/99/22/e2437.full
SO  - Neurology2022 Nov 29; 99
AB  - Background and Objectives To examine the association of the APOE ε4 and ε2 alleles with the pathologic features of patients with amyotrophic lateral sclerosis and parkinsonism-dementia complex cases in the Kii peninsula of Japan (Kii ALS/PDC).Methods We analyzed APOE variants in 18 autopsy patients with ALS/PDC, consisting of 9, 8, and 1 patient with PDC, ALS, and PDC followed by ALS, respectively. Moreover, we revealed the relationship between APOE variants and Aβ and tau pathologies.Results The frequency of the ε4 allele was not different between patients with Kii ALS/PDC and control participants. APOE ε4 was associated with increased Aβ pathology (p = 0.005 by the χ2 test), but not with increased tau pathology (p = 0.984). The frequency of the ε2 allele was apparently higher than that of control participants (p = 0.254). The APOE ε2 allele was associated with increased tau pathology (p = 0.009) and not with reduced Aβ pathology (p = 0.383) in patients with Kii ALS/PDC.Discussion Although there was no overrepresentation of the frequency of the ε4 or ε2 allele, our findings suggest that the ε2 allele is associated with increased tau pathology and not with reduced Aβ pathology in patients with Kii ALS/PDC.AD=Alzheimer disease; ALS=amyotrophic lateral sclerosis; CBD=corticobasal degeneration; PDC=parkinsonism-dementia complex