RT Journal Article SR Electronic T1 APOE Alleles With Tau and Aβ Pathology in Patients With Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex in the Kii Peninsula JF Neurology JO Neurology FD Lippincott Williams & Wilkins SP e2437 OP e2442 DO 10.1212/WNL.0000000000201156 VO 99 IS 22 A1 Sasaki, Ryogen A1 Morimoto, Satoru A1 Ozawa, Fumiko A1 Okano, Hideyuki A1 Yoshida, Mari A1 Ishiura, Hiroyuki A1 Tsuji, Shoji A1 Kuzuhara, Shigeki A1 Kokubo, Yasumasa YR 2022 UL http://n.neurology.org/content/99/22/e2437.abstract AB Background and Objectives To examine the association of the APOE ε4 and ε2 alleles with the pathologic features of patients with amyotrophic lateral sclerosis and parkinsonism-dementia complex cases in the Kii peninsula of Japan (Kii ALS/PDC).Methods We analyzed APOE variants in 18 autopsy patients with ALS/PDC, consisting of 9, 8, and 1 patient with PDC, ALS, and PDC followed by ALS, respectively. Moreover, we revealed the relationship between APOE variants and Aβ and tau pathologies.Results The frequency of the ε4 allele was not different between patients with Kii ALS/PDC and control participants. APOE ε4 was associated with increased Aβ pathology (p = 0.005 by the χ2 test), but not with increased tau pathology (p = 0.984). The frequency of the ε2 allele was apparently higher than that of control participants (p = 0.254). The APOE ε2 allele was associated with increased tau pathology (p = 0.009) and not with reduced Aβ pathology (p = 0.383) in patients with Kii ALS/PDC.Discussion Although there was no overrepresentation of the frequency of the ε4 or ε2 allele, our findings suggest that the ε2 allele is associated with increased tau pathology and not with reduced Aβ pathology in patients with Kii ALS/PDC.AD=Alzheimer disease; ALS=amyotrophic lateral sclerosis; CBD=corticobasal degeneration; PDC=parkinsonism-dementia complex