RT Journal Article
SR Electronic
T1 Parkinson's disease in twins
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 1453
OP 1453
DO 10.1212/WNL.42.8.1453
VO 42
IS 8
A1 Vieregge, P.
A1 Schiffke, K. A.
A1 Friedrich, H. J.
A1 Müller, B.
A1 Ludin, H. P.
YR 1992
UL http://n.neurology.org/content/42/8/1453.abstract
AB Among nine monozygotic (MZ) and 12 dizygotic (DZ) twin pairs in which an index case had typical Parkinson's disease (PD) or PD with associated dementia, three MZ and three DZ pairs were concordant. Three of the six affected co-twins were first diagnosed during the study. Occurrence of PD in families of MZ and DZ index cases was more frequent than expected from population prevalence rates. The study underlines the need for personal examination using defined criteria in a cross-sectional twin study on PD. Although the study did not establish a major genetic impact in the etiology of PD, a genetic predisposition for the disease cannot be ruled out for some individuals.