RT Journal Article
SR Electronic
T1 Dementia after stroke
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 1185
OP 1185
DO 10.1212/WNL.42.6.1185
VO 42
IS 6
A1 Tatemichi, T. K.
A1 Desmond, D. W.
A1 Mayeux, R.
A1 Paik, M.
A1 Stern, Y.
A1 Sano, M.
A1 Remien, R. H.
A1 Williams, J.B.W.
A1 Mohr, J. P.
A1 Hauser, W. A.
A1 Figueroa, M.
YR 1992
UL http://n.neurology.org/content/42/6/1185.abstract
AB We determined the frequency of dementia in a cohort of 251 patients aged ⩾60 years hospitalized with acute ischemie stroke, based on examinations performed 3 months after stroke onset. Using modified DSM-III-R criteria, we found dementia in 66 patients (26.3%). Diagnostic agreement among raters was excellent (kappa = 0.96). In a control sample of 249 stroke-free subjects recruited from the community and matched by age, we found dementia in eight subjects (3.2%). Using a logistic regression model to estimate the risk of dementia associated with stroke in the combined samples, the odds ratio (OR) for stroke patients compared with control subjects was 9.4 (p <0.001). Advancing age and fewer years of education were significant, independent correlates of dementia, with a trend evident for race (non-white versus white). Confining the analysis to subjects residing in the Washington Heights-Inwood community of northern Manhattan, the OR was 10.3 (p <0.001) with significant age and race effects. We conclude that ischemie stroke significantly increases the risk of dementia, with independent contributions by age, education, and race.