RT Journal Article
SR Electronic
T1 Partial dopamine agonist therapy of levodopa‐induced dyskinesias
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 1241
OP 1241
DO 10.1212/WNL.42.6.1241
VO 42
IS 6
A1 Baronti, F.
A1 Mouradian, M. M.
A1 Conant, K. E.
A1 Giuffra, M.
A1 Brughitta, G.
A1 Chase, T. N.
YR 1992
UL http://n.neurology.org/content/42/6/1241.abstract
AB We administered the partial dopamine agonist terguride under controlled conditions to patients with Parkinson's disease (PD), both as monotherapy and in conjunction with intravenous levodopa. Terguride produced a dose-dependent decrease in levodopa-induced dyskinesias (up to 53%) in seven patients without concomitant worsening of parkinsonism, and had no significant antiparkinsonian effect when administered alone. Partial dopamine agonists may hold some promise in the adjuvant therapy of patients with advanced PD.