PT  - JOURNAL ARTICLE
AU  - T. Swirsky-Sacchetti
AU  - D. R. Mitchell
AU  - J. Seward
AU  - C. Gonzales
AU  - F. Lublin
AU  - R. Knobler
AU  - H. L. Field
TI  - Neuropsychological and structural brain lesions in multiple sclerosis
AID  - 10.1212/WNL.42.7.1291
DP  - 1992 Jul 01
TA  - Neurology
PG  - 1291--1291
VI  - 42
IP  - 7
4099  - http://n.neurology.org/content/42/7/1291.short
4100  - http://n.neurology.org/content/42/7/1291.full
SO  - Neurology1992 Jul 01; 42
AB  - Quantified lesion scores derived from MRI correlate significantly with neuropsychological testing in patients with multiple sclerosis (MS). Variables used to reflect disease severity include total lesion area (TLA), ventricular-brain ratio, and size of the corpus callosum. We used these general measures of cerebral lesion involvement as well as specific ratings of lesion involvement by frontal, temporal, and parieto-occipital regions to quantify the topographic distribution of lesions and consequent effects upon cognitive function. Lesions were heavily distributed in the parieto-occipital regions bilaterally. Neuropsychological tests were highly related to all generalized measures of cerebral involvement, with TLA being the best predictor of neuropsychological deficit. Mean TLA for the cognitively impaired group was 28.30 cm2 versus 7.41 cm2 for the cognitively intact group (p < 0.0001). Multiple regression analyses revealed that left frontal lobe involvement best predicted impaired abstract problem solving, memory, and word fluency. Left parieto-occipital lesion involvement best predicted deficits in verbal learning and complex visual-integrative skills. Analysis of regional cerebral lesion load may assist in understanding the particular pattern and course of cognitive deficits in MS.