RT Journal Article
SR Electronic
T1 Dopamine‐related personality traits in Parkinson's disease
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 505
OP 505
DO 10.1212/WNL.43.3_Part_1.505
VO 43
IS 3 Part 1
A1 Menza, Matthew A.
A1 Golbe, Lawrence I.
A1 Cody, Ronald A.
A1 Forman, Nancy E.
YR 1993
UL http://n.neurology.org/content/43/3_Part_1/505.abstract
AB Studies suggest that Parkinson's disease (PD) is associated with a particular group of personality characteristics. With relative uniformity, PD patients are described as industrious, rigidly moral, stoic, serious, and nonimpulsive. In this controlled study, we used a recently developed personality questionnaire, Cloningers's Tridimensional Personality Questionnaire, to test the hypothesis that these personality traits are behavioral manifestations of damaged dopaminergic pleasure and reward systems. We found significantly less (p < 0.01) of a group of traits called ‘novelty seeking’ in PD patients compared with matched medical controls. Patients with low novelty seeking are described as being reflective, rigid, stoic, slow-tempered, frugal, orderly, and persistent, characteristics similar to those in the clinical description of PD patients. We review evidence supporting the claim that novelty seeking is dopamine-dependent, and suggest that damage to the mesolimbic dopaminergic system causes the described personality profile of PD patients.