RT Journal Article
SR Electronic
T1 Clozapine in Huntington's chorea
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 821
OP 821
DO 10.1212/WNL.44.5.821
VO 44
IS 5
A1 U. Bonuccelli
A1 R. Ceravolo
A1 C. Maremmani
A1 A. Nuti
A1 G. Rossi
A1 A. Muratorio
YR 1994
UL http://n.neurology.org/content/44/5/821.abstract
AB Article abstract –In an open-label trial, we evaluated the efficacy of clozapine on abnormal involuntary movements in five patients with Huntington's chorea. We administered clozapine at increasing doses of 25, 50, and 150 mg/d for 3 weeks. Subjective self-evaluation of all patients reported reduction of chorea and improvement of daily living activities. At the end of the trial, all patients requested to continue with clozapine. Objective evaluation with the Abnormal Involuntary Movements Scale demonstrated in all patients moderate-to-marked reduction of abnormal involuntary movements without any significant side effects; the improvement was dose-dependent and markedly decreased 1 week after drug withdrawal