RT Journal Article
SR Electronic
T1 Verbal memory impairment resulting from hippocampal neuron loss among epileptic patients with structural lesions
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 2154
OP 2158
DO 10.1212/WNL.45.12.2154
VO 45
IS 12
A1 K.J. Sass
A1 C.P. Buchanan
A1 S. Kraemer
A1 M. Westerveld
A1 J.H. Kim
A1 D.D. Spencer
YR 1995
UL http://n.neurology.org/content/45/12/2154.abstract
AB We recently demonstrated statistically significant correlations between presurgical memory impairment and hippocampal volumetric cell densities (in CA3 and the hilar area only) for patients with idiopathic left temporal lobe epilepsy who exhibited marked hippocampal neuron loss.In the present research we determine whether the same relationship exists for patients with structural lesions, in whom hippocampal neuron loss was minimal. Rank-order correlations of verbal memory test results (ie, Long Term Retrieval score of the verbal Selective Reminding Test, Percent Retention index of the Logical Memory subtest of the Wechsler Memory Scale) and hippocampal volumetric cell densities (subfields CA1, CA2, CA3, the hilar area, and the granule layer of area dentata) were computed for 22 patients with structural lesions and medically refractory epilepsy of temporal lobe onset (11 left, 11 right). There were statistically significant correlations between Long Term Retrieval and the volumetric cell density of CA1 (r equals 0.62, p less than 0.05) and between percent retention and the volumetric cell density of CA2 (r equals 0.60, p less than 0.05) for patients with left hemisphere lesions. No other correlations were found for patients with left or right temporal lobe lesions. NEUROLOGY 1995;45: 2154-2158