PT  - JOURNAL ARTICLE
AU  - A. Feigin
AU  - R. Kurlan
AU  - M.P. McDermott
AU  - J. Beach
AU  - T. Dimitsopulos
AU  - C.A. Brower
AU  - L. Chapieski
AU  - K. Trinidad
AU  - P. Como
AU  - J. Jankovic
TI  - A controlled trial of deprenyl in children with Tourette's syndrome and attention deficit hyperactivity disorder
AID  - 10.1212/WNL.46.4.965
DP  - 1996 Apr 01
TA  - Neurology
PG  - 965--968
VI  - 46
IP  - 4
4099  - http://n.neurology.org/content/46/4/965.short
4100  - http://n.neurology.org/content/46/4/965.full
SO  - Neurology1996 Apr 01; 46
AB  - We conducted a double-blind placebo-controlled crossover study to assess the efficacy of deprenyl for attention deficit hyperactivity disorder (ADHD) in children and adolescents with comorbid Tourette's syndrome (TS). Twenty-four subjects (21 boys, 3 girls; mean age 12 years) were enrolled at two sites (University of Rochester and Baylor College of Medicine). The design included two 8-week treatment periods separated by a 6-week washout period. The primary outcome measures for ADHD and tic severity were total scores on the DuPaul Attention Deficit Hyperactivity Scale (DADHS) and the Yale Global Tic Severity Scale (YGTSS). Fifteen subjects completed the study. The primary analysis revealed no statistically significant beneficial effect of deprenyl on the DADHS (mean improvement 1.3; 95% CI, minus 2.7 to 5.3; p equals 0.50). Further post-hoc analyses revealed, however, that the effect of deprenyl in the first period was substantial (p equals 0.02). There was a marginally statistically significant beneficial effect of deprenyl on the YGTSS total score (p equals 0.06). Deprenyl may improve both ADHD and tics in children with TS and warrants further study. NEUROLOGY 1996;46: 965-968.