RT Journal Article
SR Electronic
T1 A controlled trial of deprenyl in children with Tourette's syndrome and attention deficit hyperactivity disorder
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 965
OP 968
DO 10.1212/WNL.46.4.965
VO 46
IS 4
A1 A. Feigin
A1 R. Kurlan
A1 M.P. McDermott
A1 J. Beach
A1 T. Dimitsopulos
A1 C.A. Brower
A1 L. Chapieski
A1 K. Trinidad
A1 P. Como
A1 J. Jankovic
YR 1996
UL http://n.neurology.org/content/46/4/965.abstract
AB We conducted a double-blind placebo-controlled crossover study to assess the efficacy of deprenyl for attention deficit hyperactivity disorder (ADHD) in children and adolescents with comorbid Tourette's syndrome (TS). Twenty-four subjects (21 boys, 3 girls; mean age 12 years) were enrolled at two sites (University of Rochester and Baylor College of Medicine). The design included two 8-week treatment periods separated by a 6-week washout period. The primary outcome measures for ADHD and tic severity were total scores on the DuPaul Attention Deficit Hyperactivity Scale (DADHS) and the Yale Global Tic Severity Scale (YGTSS). Fifteen subjects completed the study. The primary analysis revealed no statistically significant beneficial effect of deprenyl on the DADHS (mean improvement 1.3; 95% CI, minus 2.7 to 5.3; p equals 0.50). Further post-hoc analyses revealed, however, that the effect of deprenyl in the first period was substantial (p equals 0.02). There was a marginally statistically significant beneficial effect of deprenyl on the YGTSS total score (p equals 0.06). Deprenyl may improve both ADHD and tics in children with TS and warrants further study. NEUROLOGY 1996;46: 965-968.