PT  - JOURNAL ARTICLE
AU  - Ellis, R. J.
AU  - Olichney, J. M.
AU  - Thal, L. J.
AU  - Mirra, S. S.
AU  - Morris, J. C.
AU  - Beekly, D.
AU  - Heyman, A.
TI  - Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease
AID  - 10.1212/WNL.46.6.1592
DP  - 1996 Jun 01
TA  - Neurology
PG  - 1592--1596
VI  - 46
IP  - 6
4099  - http://n.neurology.org/content/46/6/1592.short
4100  - http://n.neurology.org/content/46/6/1592.full
SO  - Neurology1996 Jun 01; 46
AB  - We studied the frequency, severity, and clinical correlations of cerebral amyloid angiopathy (CAA) in 117 CERAD subjects with autopsy-confirmed AD. Eighty-three percent showed at least a mild degree of amyloid angiopathy. Thirty of 117 brains (25.6%) showed moderate to severe CAA affecting the cerebral vessels in one or more cortical regions. These brains also showed a significantly higher frequency of hemorrhages or ischemic lesions than those of subjects with little or no amyloid angiopathy (43.3% versus 23.0%; odds ratio = 2.6, 95% CI = 1.1 to 6.2). High CAA scores also correlated with the presence of cerebral arteriosclerosis and with older age at onset of dementia. Our findings suggest that factors contributing to non-AD-related vascular pathology (e.g., atherosclerosis) may play a role in amyloid deposition in cerebral vessels in AD. NEUROLOGY 1996;46: 1592-1596