PT  - JOURNAL ARTICLE
AU  - Alderson, Lloyd M.
AU  - Noonan, Patrick T.
AU  - Choi, In Sup
AU  - Henson, John W.
TI  - Regional subacute cranial neuropathies following internal carotid cisplatin infusion
AID  - 10.1212/WNL.47.4.1088
DP  - 1996 Oct 01
TA  - Neurology
PG  - 1088--1090
VI  - 47
IP  - 4
4099  - http://n.neurology.org/content/47/4/1088.short
4100  - http://n.neurology.org/content/47/4/1088.full
SO  - Neurology1996 Oct 01; 47
AB  - The inferolateral trunk arises from the internal carotid artery at C-4 and provides vascular supply to cranial nerves III to VI. We report a patient who developed neuropathies of cranial nerves III, V1-3, and VI, 48 hours after infusion of cisplatin into the right internal carotid artery for an anaplastic oligoastrocytoma. The clinical and radiographic findings implicated direct toxicity to nerves in the distribution of the inferolateral trunk. We found additional cases by review of published brain tumor chemotherapy trials, thus identifying a novel, toxic neurovascular mechanism for injury to cranial nerves III to VI. NEUROLOGY 1996;47: 1088-1090