PT  - JOURNAL ARTICLE
AU  - Ikejiri, Y.
AU  - Mori, E.
AU  - Ishii, K.
AU  - Nishimoto, K.
AU  - Yasuda, M.
AU  - Sasaki, M.
TI  - Idebenone improves cerebral mitochondrial oxidative metabolism in a patient with MELAS
AID  - 10.1212/WNL.47.2.583
DP  - 1996 Aug 01
TA  - Neurology
PG  - 583--585
VI  - 47
IP  - 2
4099  - http://n.neurology.org/content/47/2/583.short
4100  - http://n.neurology.org/content/47/2/583.full
SO  - Neurology1996 Aug 01; 47
AB  - We report a 36-year-old man with MELAS in whom a 5-month course of high-dose oral idebenone, a derivative of coenzyme Q10, increased markedly cerebral metabolic ratio of oxygen and oxygen extraction fraction without increased cerebral blood flow with PET. The results indicate that idebenone improves mitochondrial oxidative metabolism in the brain and suggest a therapeutic potential of idebenone for MELAS. NEUROLOGY 1996;47: 583-585