RT Journal Article SR Electronic T1 Idebenone improves cerebral mitochondrial oxidative metabolism in a patient with MELAS JF Neurology JO Neurology FD Lippincott Williams & Wilkins SP 583 OP 585 DO 10.1212/WNL.47.2.583 VO 47 IS 2 A1 Ikejiri, Y. A1 Mori, E. A1 Ishii, K. A1 Nishimoto, K. A1 Yasuda, M. A1 Sasaki, M. YR 1996 UL http://n.neurology.org/content/47/2/583.abstract AB We report a 36-year-old man with MELAS in whom a 5-month course of high-dose oral idebenone, a derivative of coenzyme Q10, increased markedly cerebral metabolic ratio of oxygen and oxygen extraction fraction without increased cerebral blood flow with PET. The results indicate that idebenone improves mitochondrial oxidative metabolism in the brain and suggest a therapeutic potential of idebenone for MELAS. NEUROLOGY 1996;47: 583-585