RT Journal Article
SR Electronic
T1 Idebenone improves cerebral mitochondrial oxidative metabolism in a patient with MELAS
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 583
OP 585
DO 10.1212/WNL.47.2.583
VO 47
IS 2
A1 Ikejiri, Y.
A1 Mori, E.
A1 Ishii, K.
A1 Nishimoto, K.
A1 Yasuda, M.
A1 Sasaki, M.
YR 1996
UL http://n.neurology.org/content/47/2/583.abstract
AB We report a 36-year-old man with MELAS in whom a 5-month course of high-dose oral idebenone, a derivative of coenzyme Q10, increased markedly cerebral metabolic ratio of oxygen and oxygen extraction fraction without increased cerebral blood flow with PET. The results indicate that idebenone improves mitochondrial oxidative metabolism in the brain and suggest a therapeutic potential of idebenone for MELAS. NEUROLOGY 1996;47: 583-585