RT Journal Article
SR Electronic
T1 The search for disease-modifying treatment for Alzheimer's disease
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 35S
OP 41S
DO 10.1212/WNL.48.5_Suppl_6.35S
VO 48
IS 5 Suppl 6
A1 Paul S. Aisen
A1 Kenneth L. Davis
YR 1997
UL http://n.neurology.org/content/48/5_Suppl_6/35S.abstract
AB Article abstract-As a result of advances in the understanding of neurodegenerative mechanisms in Alzheimer's disease, several strategies for the development of disease-modifying treatment are being investigated. Nerve growth factor and other neurotrophins may improve neuronal survival, although targeted delivery remains an obstacle. Modulation of protein processing has the potential to decrease the formation of plaques and tangles. Pharmacologic reduction of oxidative stress and destructive inflammation may slow the rate of neurodegeneration. Continued research into basic mechanisms, along with therapeutic trials of promising drugs, are improving the likelihood that it will soon be possible to slow the progression of this disease. NEUROLOGY 1997;48(Suppl 6): S35-S41