RT Journal Article
SR Electronic
T1 Role of estrogen in postmenopausal depression
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 16S
OP 20S
DO 10.1212/WNL.48.5_Suppl_7.16S
VO 48
IS 5 Suppl 7
A1 Halbreich, Uriel
YR 1997
UL http://n.neurology.org/content/48/5_Suppl_7/16S.abstract
AB Article abstract-Estrogen has been reported to improve the cognitive functioning of postmenopausal women. It is suggested that estrogen replacement therapy (ERT) might be beneficial for improvement of mood and cognition in menopausal women. We have shown that this improvement is selective and is probably more apparent in complex integrative functions. We have also shown that estrogen can augment serotonergic activity as well as some norepinephrine-related processes in postmenopausal women. Because of its effects on mood-related neurotransmitter processes, ERT might decrease vulnerability to depression and be effective as an adjunct therapy to prevent treatment nonresponse to conventional antidepressants. NEUROLOGY 1997;48(Suppl 7): S16-S20