PT  - JOURNAL ARTICLE
AU  - Becker, Philip M.
AU  - Ondo, William
AU  - Sharon, Denise
TI  - Encouraging initial response of restless legs syndrome to pramipexole
AID  - 10.1212/WNL.51.4.1221
DP  - 1998 Oct 01
TA  - Neurology
PG  - 1221--1223
VI  - 51
IP  - 4
4099  - http://n.neurology.org/content/51/4/1221.short
4100  - http://n.neurology.org/content/51/4/1221.full
SO  - Neurology1998 Oct 01; 51
AB  - Restless legs syndrome (RLS) is a common condition that results in uncomfortable sensations and an urge to move the limbs. Two centers tested a new dopamine agonist, pramipexole, in 23 patients with RLS in a time-limited, open-label, clinical trial. After 4 weeks or more, 19 patients reported significant improvement as assessed by the short International Restless Legs Syndrome Study Group questionnaire (p < 0.0001). These encouraging preliminary results justify larger, controlled trials for pramipexole in patients with RLS.