RT Journal Article
SR Electronic
T1 Encouraging initial response of restless legs syndrome to pramipexole
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 1221
OP 1223
DO 10.1212/WNL.51.4.1221
VO 51
IS 4
A1 Becker, Philip M.
A1 Ondo, William
A1 Sharon, Denise
YR 1998
UL http://n.neurology.org/content/51/4/1221.abstract
AB Restless legs syndrome (RLS) is a common condition that results in uncomfortable sensations and an urge to move the limbs. Two centers tested a new dopamine agonist, pramipexole, in 23 patients with RLS in a time-limited, open-label, clinical trial. After 4 weeks or more, 19 patients reported significant improvement as assessed by the short International Restless Legs Syndrome Study Group questionnaire (p < 0.0001). These encouraging preliminary results justify larger, controlled trials for pramipexole in patients with RLS.