PT  - JOURNAL ARTICLE
AU  - M.C. Walter
AU  - H. Lochmüller
AU  - P. Reilich
AU  - T. Klopstock
AU  - R. Huber
AU  - M. Hartard
AU  - M. Hennig
AU  - D. Pongratz
AU  - W. Müller–Felber
TI  - Creatine monohydrate in muscular dystrophies: A double-blind, placebo-controlled clinical study
AID  - 10.1212/WNL.54.9.1848
DP  - 2000 May 09
TA  - Neurology
PG  - 1848--1850
VI  - 54
IP  - 9
4099  - http://n.neurology.org/content/54/9/1848.short
4100  - http://n.neurology.org/content/54/9/1848.full
SO  - Neurology2000 May 09; 54
AB  - Article abstract The authors assessed the safety and efficacy of creatine monohydrate (Cr) in various types of muscular dystrophies in a double-blind, crossover trial. Thirty-six patients (12 patients with facioscapulohumeral dystrophy, 10 patients with Becker dystrophy, 8 patients with Duchenne dystrophy, and 6 patients with sarcoglycan-deficient limb girdle muscular dystrophy) were randomized to receive Cr or placebo for 8 weeks. There was mild but significant improvement in muscle strength and daily-life activities by Medical Research Council scales and the Neuromuscular Symptom Score. Cr was well tolerated throughout the study period.