RT Journal Article
SR Electronic
T1 Creatine monohydrate in muscular dystrophies: A double-blind, placebo-controlled clinical study
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 1848
OP 1850
DO 10.1212/WNL.54.9.1848
VO 54
IS 9
A1 M.C. Walter
A1 H. Lochmüller
A1 P. Reilich
A1 T. Klopstock
A1 R. Huber
A1 M. Hartard
A1 M. Hennig
A1 D. Pongratz
A1 W. Müller–Felber
YR 2000
UL http://n.neurology.org/content/54/9/1848.abstract
AB Article abstract The authors assessed the safety and efficacy of creatine monohydrate (Cr) in various types of muscular dystrophies in a double-blind, crossover trial. Thirty-six patients (12 patients with facioscapulohumeral dystrophy, 10 patients with Becker dystrophy, 8 patients with Duchenne dystrophy, and 6 patients with sarcoglycan-deficient limb girdle muscular dystrophy) were randomized to receive Cr or placebo for 8 weeks. There was mild but significant improvement in muscle strength and daily-life activities by Medical Research Council scales and the Neuromuscular Symptom Score. Cr was well tolerated throughout the study period.