RT Journal Article
SR Electronic
T1 Quantification of tissue damage in AD using diffusion tensor and magnetization transfer MRI
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 1135
OP 1137
DO 10.1212/WNL.57.6.1135
VO 57
IS 6
A1 Bozzali, M.
A1 Franceschi, M.
A1 Falini, A.
A1 Pontesilli, S.
A1 Cercignani, M.
A1 Magnani, G.
A1 Scotti, G.
A1 Comi, G.
A1 Filippi, M.
YR 2001
UL http://n.neurology.org/content/57/6/1135.abstract
AB The authors measured mean diffusivity (D̄) and magnetization transfer ratio (MTR) of the brain from 18 patients with AD and 16 healthy control subjects. The peak heights of cortical gray matter (cGM) D̄ (p < 0.001) and MTR (p < 0.001) histograms were lower and average cGM D̄ (p < 0.01) higher in patients with AD than in control subjects. A composite MR score based on brain volume and cGM MTR peak height was correlated with patient cognitive impairment (r = 0.65, p = 0.003). This preliminary study presents a novel approach to quantify AD-related tissue damage in-vivo.