RT Journal Article
SR Electronic
T1 Increased familial risk of the psychotic phenotype of Alzheimer disease
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 907
OP 911
DO 10.1212/WNL.58.6.907
VO 58
IS 6
A1 Sweet, R. A.
A1 Nimgaonkar, V. L.
A1 Devlin, B.
A1 Lopez, O. L.
A1 DeKosky, S. T.
YR 2002
UL http://n.neurology.org/content/58/6/907.abstract
AB Background: Psychotic symptoms in patients with AD (AD with psychosis [AD+P]) define a phenotype characterized by more rapid cognitive and functional decline and a liability to aggressive behaviors. Objective: To determine if AD+P aggregates within families. Methods: Case-control study of AD+P frequency in 461 siblings of 371 probands diagnosed with AD. All siblings were ascertained as part of a genetic investigation and also were diagnosed with AD. Statistical analysis used Generalized Estimating Equations to adjust for clustering within families. Results: AD+P in probands was associated with a significantly increased risk for AD+P in family members (OR, 2.41; 95% CI 1.46–4.0; p = 0.0006). The correlation among siblings for AD+P status was modest: 0.16. Conclusion: AD+P demonstrates familial aggregation. Further studies are required to investigate a possible genetic basis of AD+P.