PT  - JOURNAL ARTICLE
AU  - Elford, K.
AU  - Leader, A.
AU  - Wee, R.
AU  - Stys, P.K.
TI  - Stroke in ovarian hyperstimulation syndrome in early pregnancy treated with intra-arterial rt-PA
AID  - 10.1212/01.WNL.0000032492.77156.35
DP  - 2002 Oct 22
TA  - Neurology
PG  - 1270--1272
VI  - 59
IP  - 8
4099  - http://n.neurology.org/content/59/8/1270.short
4100  - http://n.neurology.org/content/59/8/1270.full
SO  - Neurology2002 Oct 22; 59
AB  - Ovarian hyperstimulation syndrome (OHSS) caused by fertility medications can predispose women to thrombosis. The authors present a case of a previously healthy woman who underwent in vitro fertilization and experienced a middle cerebral artery thrombosis that was subsequently lysed with intra-arterial recombinant tissue plasminogen activator (rt-PA). To the authors’ knowledge, this is the first reported case of successful use of rt-PA to lyse a cerebral arterial thrombus resulting from severe OHSS. The patient made a near complete neurologic recovery and delivered a healthy infant at term, illustrating that intra-arterial thrombolysis can be used with relative safety even in very early pregnancy.