RT Journal Article
SR Electronic
T1 Stroke in ovarian hyperstimulation syndrome in early pregnancy treated with intra-arterial rt-PA
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 1270
OP 1272
DO 10.1212/01.WNL.0000032492.77156.35
VO 59
IS 8
A1 Elford, K.
A1 Leader, A.
A1 Wee, R.
A1 Stys, P.K.
YR 2002
UL http://n.neurology.org/content/59/8/1270.abstract
AB Ovarian hyperstimulation syndrome (OHSS) caused by fertility medications can predispose women to thrombosis. The authors present a case of a previously healthy woman who underwent in vitro fertilization and experienced a middle cerebral artery thrombosis that was subsequently lysed with intra-arterial recombinant tissue plasminogen activator (rt-PA). To the authors’ knowledge, this is the first reported case of successful use of rt-PA to lyse a cerebral arterial thrombus resulting from severe OHSS. The patient made a near complete neurologic recovery and delivered a healthy infant at term, illustrating that intra-arterial thrombolysis can be used with relative safety even in very early pregnancy.