PT  - JOURNAL ARTICLE
AU  - C.I. Prodan
AU  - N.R. Holland
AU  - P.J. Wisdom
AU  - S.A. Burstein
AU  - S.S. Bottomley
TI  - CNS demyelination associated with copper deficiency and hyperzincemia
AID  - 10.1212/01.WNL.0000032497.30439.F6
DP  - 2002 Nov 12
TA  - Neurology
PG  - 1453--1456
VI  - 59
IP  - 9
4099  - http://n.neurology.org/content/59/9/1453.short
4100  - http://n.neurology.org/content/59/9/1453.full
SO  - Neurology2002 Nov 12; 59
AB  - CNS demyelination is not a previously reported feature of acquired copper deficiency. The authors report two patients with idiopathic hypocupremia and hyperzincemia, hematologic changes of copper deficiency, and extensive CNS demyelination. Hematologic recovery followed copper supplementation, both initially and after relapse off copper therapy, while serum zinc levels remained high and the neurologic abnormalities only stabilized.