RT Journal Article
SR Electronic
T1 CNS demyelination associated with copper deficiency and hyperzincemia
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 1453
OP 1456
DO 10.1212/01.WNL.0000032497.30439.F6
VO 59
IS 9
A1 C.I. Prodan
A1 N.R. Holland
A1 P.J. Wisdom
A1 S.A. Burstein
A1 S.S. Bottomley
YR 2002
UL http://n.neurology.org/content/59/9/1453.abstract
AB CNS demyelination is not a previously reported feature of acquired copper deficiency. The authors report two patients with idiopathic hypocupremia and hyperzincemia, hematologic changes of copper deficiency, and extensive CNS demyelination. Hematologic recovery followed copper supplementation, both initially and after relapse off copper therapy, while serum zinc levels remained high and the neurologic abnormalities only stabilized.