PT  - JOURNAL ARTICLE
AU  - Boylan, G. B.
AU  - Rennie, J. M.
AU  - Chorley, G.
AU  - Pressler, R. M.
AU  - Fox, G. F.
AU  - Farrer, K.
AU  - Morton, M.
AU  - Binnie, C. D.
TI  - Second-line anticonvulsant treatment of neonatal seizures
AID  - 10.1212/01.WNL.0000106944.59990.E6
DP  - 2004 Feb 10
TA  - Neurology
PG  - 486--488
VI  - 62
IP  - 3
4099  - http://n.neurology.org/content/62/3/486.short
4100  - http://n.neurology.org/content/62/3/486.full
SO  - Neurology2004 Feb 10; 62
AB  - The authors conducted a randomized trial of second-line anticonvulsant treatments for neonates. The response to treatment was assessed using continuous video-EEG because the clinical diagnosis of seizure in neonates is known to be unreliable. Of 27 neonates with EEG-confirmed seizures, 5 were excluded because of protocol violations, and 11 responded to phenobarbitone in a dose of 40 mg/kg as first line. Three of five neonates treated with lignocaine responded. Six neonates were treated with benzodiazepines as second line: None responded, and their neurodevelopmental outcome was poor.