RT Journal Article
SR Electronic
T1 Second-line anticonvulsant treatment of neonatal seizures
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 486
OP 488
DO 10.1212/01.WNL.0000106944.59990.E6
VO 62
IS 3
A1 Boylan, G. B.
A1 Rennie, J. M.
A1 Chorley, G.
A1 Pressler, R. M.
A1 Fox, G. F.
A1 Farrer, K.
A1 Morton, M.
A1 Binnie, C. D.
YR 2004
UL http://n.neurology.org/content/62/3/486.abstract
AB The authors conducted a randomized trial of second-line anticonvulsant treatments for neonates. The response to treatment was assessed using continuous video-EEG because the clinical diagnosis of seizure in neonates is known to be unreliable. Of 27 neonates with EEG-confirmed seizures, 5 were excluded because of protocol violations, and 11 responded to phenobarbitone in a dose of 40 mg/kg as first line. Three of five neonates treated with lignocaine responded. Six neonates were treated with benzodiazepines as second line: None responded, and their neurodevelopmental outcome was poor.