PT  - JOURNAL ARTICLE
AU  - Sormani, M. P.
AU  - Rovaris, M.
AU  - Valsasina, P.
AU  - Wolinsky, J. S.
AU  - Comi, G.
AU  - Filippi, M.
TI  - Measurement error of two different techniques for brain atrophy assessment in multiple sclerosis
AID  - 10.1212/01.WNL.0000120663.85143.B3
DP  - 2004 Apr 27
TA  - Neurology
PG  - 1432--1434
VI  - 62
IP  - 8
4099  - http://n.neurology.org/content/62/8/1432.short
4100  - http://n.neurology.org/content/62/8/1432.full
SO  - Neurology2004 Apr 27; 62
AB  - The measurement errors associated with two techniques for brain atrophy assessment in multiple sclerosis (MS) were estimated. The measurement error of a semiautomated, nonnormalized technique with partial brain coverage was about twofold higher than that of a fully automated, normalized technique with full brain coverage (Structural Image Evaluation of Normalized Atrophy software [SIENA]). As shown by the analysis of data from a clinical trial of glatiramer acetate, the use of SIENA increases the study power to detect a treatment effect on brain volume changes in MS patients.