PT - JOURNAL ARTICLE AU - Sormani, M. P. AU - Rovaris, M. AU - Valsasina, P. AU - Wolinsky, J. S. AU - Comi, G. AU - Filippi, M. TI - Measurement error of two different techniques for brain atrophy assessment in multiple sclerosis AID - 10.1212/01.WNL.0000120663.85143.B3 DP - 2004 Apr 27 TA - Neurology PG - 1432--1434 VI - 62 IP - 8 4099 - http://n.neurology.org/content/62/8/1432.short 4100 - http://n.neurology.org/content/62/8/1432.full SO - Neurology2004 Apr 27; 62 AB - The measurement errors associated with two techniques for brain atrophy assessment in multiple sclerosis (MS) were estimated. The measurement error of a semiautomated, nonnormalized technique with partial brain coverage was about twofold higher than that of a fully automated, normalized technique with full brain coverage (Structural Image Evaluation of Normalized Atrophy software [SIENA]). As shown by the analysis of data from a clinical trial of glatiramer acetate, the use of SIENA increases the study power to detect a treatment effect on brain volume changes in MS patients.