RT Journal Article SR Electronic T1 Measurement error of two different techniques for brain atrophy assessment in multiple sclerosis JF Neurology JO Neurology FD Lippincott Williams & Wilkins SP 1432 OP 1434 DO 10.1212/01.WNL.0000120663.85143.B3 VO 62 IS 8 A1 Sormani, M. P. A1 Rovaris, M. A1 Valsasina, P. A1 Wolinsky, J. S. A1 Comi, G. A1 Filippi, M. YR 2004 UL http://n.neurology.org/content/62/8/1432.abstract AB The measurement errors associated with two techniques for brain atrophy assessment in multiple sclerosis (MS) were estimated. The measurement error of a semiautomated, nonnormalized technique with partial brain coverage was about twofold higher than that of a fully automated, normalized technique with full brain coverage (Structural Image Evaluation of Normalized Atrophy software [SIENA]). As shown by the analysis of data from a clinical trial of glatiramer acetate, the use of SIENA increases the study power to detect a treatment effect on brain volume changes in MS patients.