RT Journal Article
SR Electronic
T1 Measurement error of two different techniques for brain atrophy assessment in multiple sclerosis
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 1432
OP 1434
DO 10.1212/01.WNL.0000120663.85143.B3
VO 62
IS 8
A1 Sormani, M. P.
A1 Rovaris, M.
A1 Valsasina, P.
A1 Wolinsky, J. S.
A1 Comi, G.
A1 Filippi, M.
YR 2004
UL http://n.neurology.org/content/62/8/1432.abstract
AB The measurement errors associated with two techniques for brain atrophy assessment in multiple sclerosis (MS) were estimated. The measurement error of a semiautomated, nonnormalized technique with partial brain coverage was about twofold higher than that of a fully automated, normalized technique with full brain coverage (Structural Image Evaluation of Normalized Atrophy software [SIENA]). As shown by the analysis of data from a clinical trial of glatiramer acetate, the use of SIENA increases the study power to detect a treatment effect on brain volume changes in MS patients.