PT  - JOURNAL ARTICLE
AU  - Tan, N. C.K.
AU  - Heron, S. E.
AU  - Scheffer, I. E.
AU  - Pelekanos, J. T.
AU  - McMahon, J. M.
AU  - Vears, D. F.
AU  - Mulley, J. C.
AU  - Berkovic, S. F.
TI  - Failure to confirm association of a polymorphism in <em>ABCB1</em> with multidrug-resistant epilepsy
AID  - 10.1212/01.WNL.0000137051.33486.C7
DP  - 2004 Sep 28
TA  - Neurology
PG  - 1090--1092
VI  - 63
IP  - 6
4099  - http://n.neurology.org/content/63/6/1090.short
4100  - http://n.neurology.org/content/63/6/1090.full
SO  - Neurology2004 Sep 28; 63
AB  - Alteration of ATP-binding cassette subfamily B member 1 transporter (ABCB1) can plausibly cause drug-resistant epilepsy as it influences brain penetration of drugs. The CC genotype at the ABCB1 C3435T polymorphism was reported to be associated with multidrug resistance. A replication study in 401 drug-resistant and 208 drug-responsive subjects with epilepsy showed no significant association between the CC genotype and drug-resistant epilepsy. The authors suggest the initial association may have arisen by chance.