RT Journal Article
SR Electronic
T1 Failure to confirm association of a polymorphism in <em>ABCB1</em> with multidrug-resistant epilepsy
JF Neurology
JO Neurology
FD Lippincott Williams &amp; Wilkins
SP 1090
OP 1092
DO 10.1212/01.WNL.0000137051.33486.C7
VO 63
IS 6
A1 Tan, N. C.K.
A1 Heron, S. E.
A1 Scheffer, I. E.
A1 Pelekanos, J. T.
A1 McMahon, J. M.
A1 Vears, D. F.
A1 Mulley, J. C.
A1 Berkovic, S. F.
YR 2004
UL http://n.neurology.org/content/63/6/1090.abstract
AB Alteration of ATP-binding cassette subfamily B member 1 transporter (ABCB1) can plausibly cause drug-resistant epilepsy as it influences brain penetration of drugs. The CC genotype at the ABCB1 C3435T polymorphism was reported to be associated with multidrug resistance. A replication study in 401 drug-resistant and 208 drug-responsive subjects with epilepsy showed no significant association between the CC genotype and drug-resistant epilepsy. The authors suggest the initial association may have arisen by chance.