PT  - JOURNAL ARTICLE
AU  - S. Zaja-Milatovic
AU  - D. Milatovic
AU  - A. M. Schantz
AU  - J. Zhang
AU  - K. S. Montine
AU  - A. Samii
AU  - A. Y. Deutch
AU  - T. J. Montine
TI  - Dendritic degeneration in neostriatal medium spiny neurons in Parkinson disease
AID  - 10.1212/01.WNL.0000150591.33787.A4
DP  - 2005 Feb 08
TA  - Neurology
PG  - 545--547
VI  - 64
IP  - 3
4099  - http://n.neurology.org/content/64/3/545.short
4100  - http://n.neurology.org/content/64/3/545.full
SO  - Neurology2005 Feb 08; 64
AB  - Dysfunction of neostriatal medium spiny neurons (MSNs) is hypothesized to underlie late-stage motor complications of Parkinson disease (PD). The authors demonstrate shortened dendrite length of MSNs that was similar in four regions of neostriatum in late-stage PD. In contrast, MSN dendrite spine degeneration was unevenly distributed with the greatest loss in caudal putamen. The authors propose that these structural changes in MSN may contribute to late-stage motor complications of PD.