RT Journal Article
SR Electronic
T1 Dendritic degeneration in neostriatal medium spiny neurons in Parkinson disease
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 545
OP 547
DO 10.1212/01.WNL.0000150591.33787.A4
VO 64
IS 3
A1 S. Zaja-Milatovic
A1 D. Milatovic
A1 A. M. Schantz
A1 J. Zhang
A1 K. S. Montine
A1 A. Samii
A1 A. Y. Deutch
A1 T. J. Montine
YR 2005
UL http://n.neurology.org/content/64/3/545.abstract
AB Dysfunction of neostriatal medium spiny neurons (MSNs) is hypothesized to underlie late-stage motor complications of Parkinson disease (PD). The authors demonstrate shortened dendrite length of MSNs that was similar in four regions of neostriatum in late-stage PD. In contrast, MSN dendrite spine degeneration was unevenly distributed with the greatest loss in caudal putamen. The authors propose that these structural changes in MSN may contribute to late-stage motor complications of PD.