RT Journal Article
SR Electronic
T1 Efficacy of coenzyme Q10 in migraine prophylaxis: A randomized controlled trial
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 713
OP 715
DO 10.1212/01.WNL.0000151975.03598.ED
VO 64
IS 4
A1 Sándor, P. S.
A1 Di Clemente, L.
A1 Coppola, G.
A1 Saenger, U.
A1 Fumal, A.
A1 Magis, D.
A1 Seidel, L.
A1 Agosti, R. M.
A1 Schoenen, J.
YR 2005
UL http://n.neurology.org/content/64/4/713.abstract
AB Riboflavin, which improves energy metabolism similarly to coenzyme Q10 (CoQ10), is effective in migraine prophylaxis. We compared CoQ10 (3 × 100 mg/day) and placebo in 42 migraine patients in a double-blind, randomized, placebo-controlled trial. CoQ10 was superior to placebo for attack-frequency, headache-days and days-with-nausea in the third treatment month and well tolerated; 50%-responder-rate for attack frequency was 14.4% for placebo and 47.6% for CoQ10 (number-needed-to-treat: 3). CoQ10 is efficacious and well tolerated.