PT  - JOURNAL ARTICLE
AU  - Julián Benito-León
AU  - Elan D. Louis
AU  - Félix Bermejo-Pareja
ED  - ,
TI  - Elderly-onset essential tremor is associated with dementia
AID  - 10.1212/01.wnl.0000216134.88617.de
DP  - 2006 May 23
TA  - Neurology
PG  - 1500--1505
VI  - 66
IP  - 10
4099  - http://n.neurology.org/content/66/10/1500.short
4100  - http://n.neurology.org/content/66/10/1500.full
SO  - Neurology2006 May 23; 66
AB  - Objective: To determine whether essential tremor (ET) is associated with prevalent dementia. Methods: The authors identified all persons with dementia and ET in a population-based study in central Spain (the Neurological Disorders in Central Spain [NEDICES] Study). Dementia was diagnosed using the Diagnostic and Statistical Manual of Mental Disorders (4th ed.) criteria. Results: Thirty-one (11.4%) of 273 ET cases had dementia vs 204 (6.0%) of 3,382 non-ET subjects (controls) (odds ratio [OR] = 2.00, 95% CI = 1.34 to 2.98, p = 0.001). In a model that adjusted for age, stroke, and educational level, OR = 1.35, 95% CI = 0.87 to 2.18, and p = 0.17. In an adjusted model, ET cases with tremor onset after age 65 were 70% more likely to be demented than were controls (OR = 1.70, 95% CI = 1.04 to 2.76, p = 0.03), whereas ET cases with tremor onset at age ≤65 and controls were equally likely to be demented (OR = 0.38, 95% CI = 0.09 to 1.73, p = 0.21). Conclusions: Older-onset essential tremor (ET) was associated with dementia. Prospective studies are required to elucidate the association between ET and dementia.