PT - JOURNAL ARTICLE AU - Whitwell, Jennifer L. AU - Jack, Clifford R. AU - Senjem, Matthew L. AU - Josephs, Keith A. TI - Patterns of atrophy in pathologically confirmed FTLD with and without motor neuron degeneration AID - 10.1212/01.wnl.0000191395.69438.12 DP - 2006 Jan 10 TA - Neurology PG - 102--104 VI - 66 IP - 1 4099 - http://n.neurology.org/content/66/1/102.short 4100 - http://n.neurology.org/content/66/1/102.full SO - Neurology2006 Jan 10; 66 AB - The authors used voxel-based morphometry to compare the patterns of brain atrophy in two variants of pathologically confirmed frontotemporal lobar degeneration (FTLD): FTLD with motor neuron disease (FTLD-MND) and FTLD with ubiquitin-only-immunoreactive neuronal changes (FTLD-U). Patterns of atrophy were distinct and different from each other. A localized pattern of frontal lobe atrophy was found in FTLD-MND with a more widespread pattern of atrophy affecting the frontal and temporal lobes in FTLD-U.