PT  - JOURNAL ARTICLE
AU  - Kimura, F.
AU  - Fujimura, C.
AU  - Ishida, S.
AU  - Nakajima, H.
AU  - Furutama, D.
AU  - Uehara, H.
AU  - Shinoda, K.
AU  - Sugino, M.
AU  - Hanafusa, T.
TI  - Progression rate of ALSFRS-R at time of diagnosis predicts survival time in ALS
AID  - 10.1212/01.wnl.0000194316.91908.8a
DP  - 2006 Jan 24
TA  - Neurology
PG  - 265--267
VI  - 66
IP  - 2
4099  - http://n.neurology.org/content/66/2/265.short
4100  - http://n.neurology.org/content/66/2/265.full
SO  - Neurology2006 Jan 24; 66
AB  - The authors calculated the progression rate (ΔFS) using the total revised ALS Functional Rating Scale (ALSFRS-R) and symptom duration at diagnosis in 82 Japanese patients with ALS. Survival (death or tracheostomy) differed significantly with the ΔFS and postdiagnostic period according to log-rank testing, but Cox proportional hazards modeling revealed no strong association between total ALSFRS-R and mortality, suggesting that the ΔFS provides an additional predictive index beyond ALSFRS-R alone.