RT Journal Article
SR Electronic
T1 Progression rate of ALSFRS-R at time of diagnosis predicts survival time in ALS
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 265
OP 267
DO 10.1212/01.wnl.0000194316.91908.8a
VO 66
IS 2
A1 Kimura, F.
A1 Fujimura, C.
A1 Ishida, S.
A1 Nakajima, H.
A1 Furutama, D.
A1 Uehara, H.
A1 Shinoda, K.
A1 Sugino, M.
A1 Hanafusa, T.
YR 2006
UL http://n.neurology.org/content/66/2/265.abstract
AB The authors calculated the progression rate (ΔFS) using the total revised ALS Functional Rating Scale (ALSFRS-R) and symptom duration at diagnosis in 82 Japanese patients with ALS. Survival (death or tracheostomy) differed significantly with the ΔFS and postdiagnostic period according to log-rank testing, but Cox proportional hazards modeling revealed no strong association between total ALSFRS-R and mortality, suggesting that the ΔFS provides an additional predictive index beyond ALSFRS-R alone.